What Is NAC?

N-acetylcysteine (NAC) is a powerful antioxidant and anti-inflammatory amino acid derivative.

 

It helps your body:

Rebuild glutathione, your master detoxifying molecule

• Reduce oxidative stress, which is elevated in endometriosis

• Thin mucus and fluid buildup in tissues

• Support the immune system and reduce pelvic inflammation

• Break down biofilms, which may be involved in deep infiltrating endometriosis

 

NAC has been studied for its ability to reduce endometrial lesion size, modulate inflammatory

markers, and improve fertility outcomes — all without the side effects of hormone suppression.

 

Why Use NAC After Endometriosis Surgery?

After excision surgery, your body enters a state of inflammation and repair. IV NAC can help:

• Prevent adhesion formation by reducing oxidative stress

• Speed up tissue healing and detoxification from anesthesia and inflammation

• Support liver function during medication metabolism

• Reduce post-op pain and flare-up severity

• Improve immune regulation and hormone detox

 

NAC is especially important for patients with MTHFR mutations, who may have impaired

glutathione synthesis or difficulty clearing estrogen and toxins post-op.

 

How IV NAC Works Differently Than Oral

IV NAC bypasses the gut and delivers high concentrations of NAC directly into your

bloodstream — giving your cells immediate access to this antioxidant.

Benefits of IV NAC vs. Oral:

• Faster onset of action (immediate absorption)

• Higher plasma levelsachievable than oral form

• Better tolerance for patients with GI issues or malabsorption

• More effective during acute inflammation, flare-ups, or post-op periods

 

At Elysara, we often recommend a short series of IV NAC infusions after surgery or during

severe flare-ups, followed by maintenance with oral NAC.

 

What to Expect with IV NAC at Elysara

• IV infusion time: approximately 45–60 minutes

• Frequency: 1–2x weekly for 2–4 weeks depending on your case

• Common pairing: Vitamin C, Magnesium, Glutathione, B-complex, and Zinc for

enhanced synergy

• Most patients report improved energy, reduced bloating, and less pelvic painwithin the

first few sessions

 

We use a proprietary anti-inflammatory formula tailored to endometriosis recovery — not just

generic IV therapy.

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TRANSITIONING TO ORAL NAC

Once your body has stabilized, we gradually transition you to oral NAC for long-term

maintenance.

 

Oral NAC Guidelines:

• Typical dose: 600–1800 mg/day, divided in 2 doses

• Best taken on an empty stomach

• Combine with Vitamin C and B6 to support detoxification pathways

• use during flare-ups, around ovulation, or premenstrually if symptoms return

 

We may pair oral NAC with DIM, calcium D-glucarate, curcumin, or glutathione precursors

based on your labs and symptoms.

 

SCIENTIFIC SUPPORT FOR NAC IN ENDOMETRIOSIS

• Reduced Lesion Size: A 2013 study by Porpora et al. found NAC reduced endometrioma

size and pain scores over 3 months (Porpora et al., 2013).

• Improved Fertility: NAC has shown benefits for ovulatory regulation and cervical

mucus in PCOS and endometriosis.

• Immune Regulation: NAC modulates cytokines and reduces TNF-α and IL-6 — key

• inflammatory signals in endometriosis.

• Detox Pathway Support: NAC is a direct precursor to glutathione and supports phase II

liver detox — essential for estrogen clearance.

 

IV NAC & oral NAC is a cornerstone of functional support for endometriosis patients —

especially after surgery, during flare-ups, or when inflammation persists.

 

We personalize your NAC protocol based on:

• Genetics (like MTHFR status)

• Lab markers

• Surgical history

• Hormonal and inflammatory symptoms